Neprinol targets the underlying causes of Peyronie's disease
Peyronie’s disease
Peyronie’s disease is a penis disorder in which fibers form plaques, causing abnormal curvature, pain and, in severe cases, erectile dysfunction and impotence. Peyronie’s disease can also have a severe psychological impact: nearly half of affected men in one study were found to suffer from depression [1]. Peyronie’s disease is notoriously difficult to treat, but Neprinol, a supplement that targets the root cause of Peyronie’s disease, may offer a promising alternative to traditional treatments.
Although the disease was originally thought to be rare, more recent studies have indicated that between 3% and 9% of adult men are affected [2,3]. Peyronie’s disease is more common in men over 40 and more likely to occur after an injury, such as a minor trauma during sex, surgery or exposure to a sexually transmitted disease. Men may have a genetic predisposition to the disease and smoking, alcohol consumption, diabetes and hypertension may also increase the risk of developing Peyronie’s disease [4].
Fibrin is critical to the development of Peyronie’s disease
The formation of Peyronie’s disease plaques is thought to arise from the presence of fibers called fibrin in the soft tissue of the penis. Fibrin is an insoluble protein that is used for blood clotting, scar formation and many other biological functions by creating a scaffold that allows cells or proteins to stick together. Although it clearly plays an important role in maintaining health, excess fibrin has been linked to the formation of dangerous blood clots that can cause heart attack, stroke, pulmonary embolism and related disorders [5,6].
Excess fibrin is normally broken down and dissolved by an enzyme called plasmin. Plasmin levels are controlled by enzymes, chemical messengers and regulatory proteins that are needed for plasmin formation. Fibrin levels in the blood tend to increase with age due to less of the enzymes and other proteins needed to make plasmin. Many of the risk factors for Peyronie’s disease, such as diabetes and smoking, have also been shown to increase fibrin in the body.
In Peyronie’s disease, microscopic injury to the penis or another trigger is thought to allow fibrin to escape from the blood into the soft tissue of the penis. The presence of fibrin then sets off a cascade of chemical signals that ultimately results in the formation of plaques. Like scar tissue, these plaques consist mostly of collagen, a type of protein that is abundant in muscle, tendons, ligaments, and skin [7].
Unfortunately for affected patients, treatments for Peyronie’s disease have shown only limited success. Various drug therapies have been investigated, but none have proven effective in randomized, placebo-controlled clinical trials [8]. Surgical procedures can reduce symptoms in severe cases, but surgery carries greater risks and commonly results in shortening of the penis and other negative effects that lower patient satisfaction [9].
Neprinol lowers fibrin levels to reduce the symptoms of Peyronie’s
Neprinol is a blend of protein-dissolving enzymes that are able to slow fibrin production and break down fibrin to remove plaques [10]. Perhaps the most significant enzyme for Peyronie’s included in Neprinol is nattokinase, an enzyme derived from a popular Japanese fermented soy product that is 4 times more powerful than plasmin at breaking down fibrin [11]. Serrapeptase, an enzyme in Neprinol that is from silk worms, increases fibrin break down and removal plus also has anti-inflammatory effects [12]. Bromelain, a pineapple extract, contains various protein-dissolving enzymes that act on multiple steps in the process of fibrin break down to lower fibrin levels [13].
Thus, the blend of enzymes in Neprinol has the ability actively break down existing plaques while also lowering the chances for new plaque formation. They also strengthen the immune system and blood circulation in the area.
No large-scale studies on the use of Neprinol to treat Peyronie’s disease have been conducted to date. However, Neprinol has shown excellent results in the treatment of other disorders related to fibrin and the formation of excessive scar tissue, such as pulmonary fibrosis. In the past, the best hope for most men with Peyronie’s disease was that the disease would eventually resolve itself, but that occurs in only a small percentage of patients. Given the absence of effective traditional treatment options, the consistent use of Neprinol may be an excellent natural alternative approach for men with Peyronie’s disease.
SUGGESTED DOSAGE
Begin taking 3 pills, 3 times a day until the pain and curvature are eliminated. Once a normal erection is achieved, reduce the dosage to only 2 pills, 3 times a day for the next few months. At this point you may begin to taper your dosage to less than six per day. If symptoms begin to reappear, immediately increase your dosage until symptoms disappear. Continue at this dosage to prevent the symptoms from reappearing. In some extreme cases, full remission is not possible, but a majority of the curvature and pain are eliminated. Neprinol is not a cure for the Peyronies condition, but may effectively eliminate the symptoms. In most cases when patients have discontinued the Neprinol, symptoms did return over time. Once the discomfort has been eliminated, a moderate preventive dose is strongly recommended.
Dr. Theodore R. Herazy
Peyronie's Disease Institute
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
Nelson CJ, Diblasio C, Kendirci M, Hellstrom W, Guhring P, Mulhall JP. The chronology of depression and distress in men with Peyronie’s disease. J Sex Med. 2008;5(8):1985-1990.
Schwarzer U, Sommer F, Klotz T, Braun M, Reifenrath B, Engelmann U. The prevalence of Peyronie’s disease: results of a large survey. BJU Int. 2001; 88(7):727-730.
Mulhall JP, Creech SD, Boorjian SA, Ghaly S, Kim ED, Moty A, Davis R, Hellstrom W. Subjective and objective analysis of the prevalence of Peyronie’s disease in a population of men presenting for prostate cancer screening. J Urol. 2004;171(6 pt 1):2350-2353.
Bjekic MD, Vlajinac HO, Sipetic SB, Marinkovic JM. Risk factors for Peyronie’s disease: a case-control study. BJU Int. 2006;97(3):570-574.
Eidelman RS, Hennekens CH. Fibrinogen: a predictor of stroke and marker of atherosclerosis. Eur Heart J. 2003;24:499-500.
Koenig W. Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost. 2003;89:601-609.
Jalkut M, Gonzalez-Cadavid N, Rajfer J. Peyronie’s disease: a review. Rev Urol. 2003;5(3):142-148.
Hellstrom W. Medical management of Peyronie’s disease. J Androl. 2009; 30(4):397-405.
Tran VQ, Kim DH, Lesser TF, Aboseif SR. Review of the surgical approaches for Peyronie’s disease: corporeal plication and plaque incision with grafting. Adv Urol. 2008; 263450.
Meletis CD, Barker JE. Therapeutic enzymes: using the body’s helpers as healers. Alt Comp Ther. 2005;74-77.
Fujita M, Hong K, Ito Y, Fujii R, Kariya K, Nishimuro S. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biol Pharm Bull. 1995;18:1387-1391.
Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S, Guarini E, Vesperini G. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-388.
Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58:1234-1245.
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